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相关概念视频

Longitudinal Research02:20

Longitudinal Research

12.5K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.5K
Aging01:26

Aging

182
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
182
Cross-Sectional Research01:50

Cross-Sectional Research

11.8K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
11.8K
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

275
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
275
Longitudinal Studies01:26

Longitudinal Studies

247
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
247
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K

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相关实验视频

Updated: Sep 11, 2025

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

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从横截面数据中描述正在进行的大脑衰老和基线效应.

Stephen M Smith1, Karla L Miller1, Thomas E Nichols1,2

  • 1Oxford Centre for Functional MRI of the Brain (FMRIB/WIN), Oxford University, Oxford, United Kingdom.

Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
PubMed
概括

大脑年龄三角值,即估计年龄和实际年龄之间的差异,可能会产生误导. 新的方法揭示了不同的大脑衰老模式,将真正的衰老率与基线效应分开,并显示横截面和纵向数据之间的一致性.

科学领域:

  • 神经成像是一种神经成像.
  • 生物统计学 生物统计学
  • 老年学是一门学科.

背景情况:

  • 大脑年龄三角形,大脑预测年龄和时间表年龄之间的差异,是加速大脑衰老的标志物.
  • 截面数据经常将真正的衰老率与稳定的个体差异 (基线效应) 混为一谈.
  • 区分这些因素对于准确解释大脑衰老至关重要.

研究的目的:

  • 开发和验证一种方法,使用横截面数据将不同的大脑衰老率与固定基线效应分开.
  • 调查是否存在不同的大脑衰老模式,以及它们与衰老率的关系.
  • 为了调和横截面和纵向大脑衰老发现之间的差异.

主要方法:

  • 开发了一种新的统计方法来分析横截面脑成像数据,估计多种不同的脑衰老模式.
  • 利用了4400名英国生物库参与者的纵向数据进行模型验证.
  • 实施仔细的数据处理,以确保不同研究设计之间的一致性.

主要成果:

  • 估计每个受试者的单个大脑年龄三角值的常用方法主要是基线效应.
  • 分析揭示了大脑衰老的不同模式,其中一些模式强烈反映了不同个体的衰老速度.
  • 在适当的数据处理后,经过横截面和纵向大脑衰老分析之间的一致性得到证明.
关键词:
大脑衰老 老龄化脑部成像 脑部成像

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

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结论:

  • 单个大脑年龄三角形不足以准确地捕捉个体的衰老轨迹.
  • 识别多种模式的脑衰老提供了一个更细致的理解神经发育和衰老.
  • 拟议的方法协调了横截面和纵向发现,提高了作为生物标志物的大脑年龄的可靠性.