尾状功能组织的脱差与降低D1多巴胺受体的可用性和衰老中的较差记忆功能有关
Saana M Korkki1,2, Jarkko Johansson3,4, Kristin Nordin1
1Aging Research Center, Karolinska Institute and Stockholm University, Solna, Sweden.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
类似多巴胺D1的受体对于维持老化大脑的认知功能至关重要. 较低的受体可用性与老年人脑电路特异性降低和记忆力下降有关.
科学领域:
- 神经科学是一个神经科学.
- 认知老龄化 认知老龄化
- 神经成像是一种神经成像.
背景情况:
- 与年龄相关的认知能力下降与皮层-状功能变化有关.
- 这些变化背后的机制,特别是多巴胺的作用,尚未完全理解.
- 计算模型表明多巴胺缺乏会损害神经增益控制和电路特异性.
研究的目的:
- 为了研究多巴胺D1类受体 (D1DRs) 与皮质-状功能在整个生命周期之间的关系.
- 确定D1DR可用性如何影响衰老中的功能合.
- 将这些神经变化与认知能力,特别是记忆力联系起来.
主要方法:
- 在一个大寿命队列 (n=180) 上利用多式神经成像 (fMRI,PET).
- 在休息和n-back工作记忆任务期间评估皮质-状回路的功能连接性.
- 与功能合特异性和内存性能相关的D1DR可用性.
主要成果:
- 观察到与年龄相关的中心侧尾状和皮质网络之间的功能合特异性的下降.
- 这种在休息和工作记忆期间减少的特异性与较差的记忆性能相关.
- 尾状和前额叶皮层中较低的D1DR可用性预测了较少的差异化合,部分解释了与年龄相关的下降.
结论:
- 多巴胺在衰老过程中在保持皮质-状回路的功能专业化方面发挥着至关重要的作用.
- 这些研究结果支持计算模型,该模型将儿科胺激素衰退与与年龄相关的大脑脱差联系起来.
- 多巴胺调节对于在老年时保持认知灵活性和记忆力至关重要.
更多相关视频
相关概念视频
Alzheimer's Disease: Overview
668
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
668
Dementia
165
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
165
Cognitive Development During Adulthood
275
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
275
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Role of Cerebellum and Prefrontal Cortex in Memory
575
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
575
Parkinson's Disease: Overview
704
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
704


