在人类中,三角骨-侧侧-中枢杏仁体通道的划定
Batu Kaya1,2,3, Omar Khalil1,2,3, Spencer S Abssy1,3
1Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
研究人员在人类中发现了一种新型的大脑电路,即三神经 (CN V) - 侧侧核 (PBN) - 中枢桃体 (CeA). 这种途径可以解释口腔面部疼痛的强烈不愉快性,并提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 疼痛研究 疼痛研究
背景情况:
- 副核 (PBN) 向边缘区域传递感官信息,侧面的PBN投射到中央杏仁体 (CeA) 可能编码疼痛影响.
- 面部或面部疼痛被认为比其他地方的疼痛更不愉快,可能是由于面部在社交互动和养中的作用.
- 虽然假设三角神经 (CN V) - 侧面PBN-CeA电路能够调解这种增加的负面影响,但其在人类中的存在仍未得到证实.
研究的目的:
- 通过扩散核磁共振 (MRI) 在人类大脑中划分三角神经 (CN V) - 侧侧侧脑核 (PBN) - 中枢桃体 (CeA) 电路.
- 为了研究在7T和3TMRI场强度下解决该电路的可行性.
- 为了探索这种电路的连接强度的潜在性别差异.
主要方法:
- 概率曲谱被应用到来自人类结合体项目 (HCP) 数据集的扩散MRI数据 (n=150在7T,n=155在3T).
- 划定了CN V侧面PNN-CeA通路,并与涉及底侧杏仁体 (BLAT) 的对照通路进行了比较.
- 分析了连接强度,特别关注3T的潜在基于性别的差异.
主要成果:
- 在7T和3T时,CN V-lateral PBN-CeA电路在人体中成功地被划定为*in vivo*.
- 在两个场强度下,CN V-lPBN-CeA通路的连接强度明显大于对照CN V-lPBN-BLAT通路 (p < 0.001).
- 观察到一个显著的性别差异,在右CN V-lPBN-CeA电路中,与女性相比,男性在3T (p = 0.002) 中的连接性更强.
结论:
- 这项研究提供了人类CN V-lateral PBN-CeA电路的第一个*in vivo*划分.
- 这个电路代表了一个潜在的神经解剖学基质,有助于与口腔面部疼痛相关的负面影响.
- 鉴定的途径可以作为一种新的治疗点,用于管理面部或面部疼痛条件.
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