新生儿功能连接的个体模式,由基于表面的贝叶斯模型揭示.
Diego Derman1, Damon D Pham2, Amanda F Mejia2
1Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, United States.
Imaging neuroscience (Cambridge, Mass.)
|August 13, 2025
概括
研究人员使用先进的fMRI分析绘制婴儿个体大脑网络的地图. 这项研究揭示了与年龄相关的大脑连接的变化,突出了婴儿之间的差异.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 神经成像是一种神经成像.
背景情况:
- 休息状态功能连接 (rsFC) 对于理解大脑发育至关重要.
- 由于数据采集的复杂性,估计婴儿的rsFC具有挑战性.
- 以前的方法很难捕捉婴儿大脑网络中的个体变异性.
研究的目的:
- 描述大脑网络组织的个体变异性,在一个大队伍的出生婴儿.
- 开发和验证一个新的数据驱动的贝叶斯框架用于婴儿fMRI分析.
- 研究早期发育中的年龄和功能性大脑连接之间的关系.
主要方法:
- 利用了来自人类结合体项目 (dHCP) 数据库中的289名婴儿的静止状态fMRI数据.
- 采用了新的数据驱动的贝叶斯框架来进行网络估计.
- 在皮质表面进行了分析,使用基于表面的记录与新生儿图谱进行了增强对齐.
主要成果:
- 成功估计了八个不同的大脑网络的主体级地图.
- 生成了个别的功能分片地图,揭示了显著的学科间差异.
- 确定了婴儿年龄和所有大脑区域的平均连接强度之间的显著积极关系,包括更高阶网络.
结论:
- 这项研究证明了基于表面的方法和贝叶斯方法分析婴儿fMRI数据的有效性.
- 这些发现为早期大脑网络组织中的个体变异性和与年龄相关的变化提供了新的见解.
- 这一框架推动了对非常年轻人群中神经发育轨迹的研究.
更多相关视频
08:36Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
Published on: March 21, 2019
7.3K
08:51Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
Published on: November 1, 2019
5.7K
相关概念视频
Neuron Structure
Overview
Molecular Models
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
Fluid Mosaic Model
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
Neuron Structure
Neurons are the main type of cell in the nervous system that generate and transmit electrochemical signals. They primarily communicate with each other using neurotransmitters at specific junctions called synapses. Neurons come in many shapes that often relate to their function, but most share three main structures: an axon and dendrites that extend out from a cell body.
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to cellular...
Structure and Function of Neurons
The neuronal cell body—the soma— houses the nucleus and organelles vital to cellular...
Overview of Cell-Matrix Interactions
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Embryonic Connective Tissues
During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
