通过网络药理学和实验验证验,通过网络药理学和实验验证验,研究武灵山在糖尿病病中的潜在标
Xicheng Hu1, Zhen Wang2, Liyan Zhang2
1Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Frontiers in molecular biosciences
|August 13, 2025
概括
武灵山 (WLS) 通过向多个途径来治疗糖尿病病 (DN),抑制炎症和纤维化. 这项研究阐明了WLS.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
- 糖尿病病研究 糖尿病病研究
背景情况:
- 糖尿病病 (DN) 是糖尿病的一种严重并发症,有效治疗方法有限.
- 武灵山 (WLS) 是一种传统的中医药,对DN有希望,但其机制尚不清楚.
- 了解WLS的多目标作用对于开发新的DN疗法至关重要.
研究的目的:
- 阐明武灵山 (WLS) 在治疗糖尿病病 (DN) 的分子机制.
- 通过网络药理学和分子对接来确定WLS规范的关键目标和途径.
- 为了验证WLS对脏细胞in vitro的影响.
主要方法:
- 网络药理学用于选WLS活性成分和DN目标.
- 生物信息学分析 (GO,KEGG,PPI) 以确定关键途径和目标.
- 分子对接和动力学模拟以评估结合亲和力和稳定性.
- 在体外实验中使用高葡萄糖诱导的HK-2细胞来评估WLS效应.
主要成果:
- 确定了SRC,AKT1,TNF,ESR1和HSP90AA1作为DN治疗的关键目标.
- WLS主要调节PI3K-Akt和MAPK信号通路.
- 分子对接证实了WLS组件 (例如β-caryophyllene) 与目标 (例如TNF) 的稳定结合.
- 实验室研究表明,WLS抑制了HK-2细胞增殖和诱导细胞循环停止.
结论:
- 武灵山 (WLS) 通过向多个分子和途径来治疗糖尿病病 (DN).
- WLS抑制炎症,氧化应激和纤维化,为其临床使用提供了理论基础.
- 需要进一步的体内研究来证实WLS在DN中的治疗功效.
更多相关视频
12:34Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
Published on: January 12, 2024
902
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
175
相关概念视频
02:26Protein Networks
4.1K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.1K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.8K
02:54Canonical Wnt Signaling Pathway
8.9K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.9K
01:41Non-Canonical Wnt Signaling Pathways
7.4K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.4K