杏仁体和基底核的联合功能障碍是帕金森病中视觉幻觉的基础
Anna Ignatavicius1,2, Lachlan Churchill1,2, Jack Anderson1,2
1Central Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
概括
帕金森病中的视觉幻觉与杏仁体和注意力网络之间的连接受损有关,部分原因是胆功能障碍. 这些变化独立于大脑缩而发生.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 视觉幻觉 (VHs) 在帕金森病 (PD) 中很常见,与感官整合和注意力障碍有关.
- 杏仁体病理和胆性缺陷与跨同核蛋白病变的VH有关.
- 在PDVH中这些因素之间的相互作用尚未得到充分理解.
研究的目的:
- 调查杏仁体和胆功能障碍对PD中VH的联合作用.
- 探索帕金森病中VHs背后的神经生物学机制.
主要方法:
- 70名PD患者 (30名有VH,40名没有) 接受了MRI扫描.
- 基于种子的分析检查了杏仁体,Meynert基底核 (NBM) 和皮质网络之间的功能连接.
- 与VHs,杏仁体和NBM体积相关的连接性被评估.
主要成果:
- 患有VH的患者表现出杏仁体与视觉和注意力网络的连接性减少.
- 在患有VHs的PD患者中观察到左桃体与背部和腹部注意力网络的连接性减少.
- 杏仁体注意力网络失联部分是由左NBM-腹部注意力网络相互作用介导的,独立于大脑缩.
结论:
- 在PD中,VH与连接杏仁体,胆固醇系统和注意力/感知网络的功能性连接受损有关.
- 这些发现揭示了神经回路之间的相互作用,这些神经回路有助于PD VHs.
- 这项研究为帕金森病中VHs的病理生理学提供了新的见解.
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