对道内皮层瘤的干预措施
Torben B Pedersen1, Frederik Rønne Pachler2, Jacob Rosenberg3
1Deparment of Surgery, Herlev and Gentofte Hospital, Copenhagen, Denmark.
The Cochrane database of systematic reviews
|August 13, 2025
概括
内皮质瘤 (AIN) 治疗可能会降低艾滋病毒感染者的门癌症风险. 然而,证据质量非常低,需要进一步研究以得出关于AIN干预的最终结论.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 门内皮质瘤 (AIN) 是一种与HPV感染相关的癌前门病变,发病率越来越高.
- 高度AIN可以发展为门癌,特别是在高风险群体中,如艾滋病毒感染者和与男性发生性关系的男性 (MSM).
- 目前的治疗方法包括废除疗法和局部药物,旨在降低复发率和并发症率.
研究的目的:
- 评估治疗内皮质瘤 (AIN) 的治疗干预措施的有效性.
- 评估结果,如AIN根除,门癌症的发展,和人类乳头瘤病毒 (HPV) 根除.
- 确定与AIN治疗相关的对生活质量和不良事件的影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查.
- 搜索包括CENTRAL,MEDLINE,Embase和试验注册表,数据更新至2025年4月16日.
- 包括5个RCT,涉及4907名参与者,所有参与者都是艾滋病毒感染的成年人.
主要成果:
- 与主动监测相比,高分辨率无光镜 (HRA) 引导的治疗显示出门癌症风险的潜在降低 (0.4%与0.9%相比),尽管证据非常不确定.
- 治疗组和监测组之间在身体或心理功能方面没有发现显著差异.
- 治疗组中不良事件比较常见 (2%对比0.2%),主要是轻微的疼痛.
结论:
- 对于AIN干预的证据,包括HRA导向治疗,确定性非常低,限制了最终的结论.
- 需要进一步的高质量,充足的研究来确定各种AIN治疗的疗效.
- 在HIV阴性人群中对AIN干预措施的研究也是有必要的.
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