巨 Elesdenii 调节不良结肠上皮质平衡,加剧结肠炎相关的瘤发生
Xinxin Hou1, Zhaozhou Zhang1, Wanqing Chen2
1School of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 13, 2025
概括
肠道细菌Megasphaera,特别是M. elsdenii,通过激活免疫细胞来驱动结肠炎症和癌症. 这一发现对于理解炎症性肠道疾病和结直肠癌的发病过程至关重要.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 改变的肠道微生物群与结肠炎和结肠直肠癌 (CRC) 有关.
- 驱动结肠炎症和瘤发生的特定细菌机制尚不清楚.
- 肠道细菌属Megasphaera在炎症性肠病 (IBD) 和CRC患者中被发现是丰富的.
研究的目的:
- 为了调查Megasphaera,特别是M. elsdenii在结肠炎症和瘤发生中的作用.
- 为了阐明参与Megasphaera诱导的炎症的免疫路径.
- 评估Megasphaera与早期CRC的相关性.
主要方法:
- 在IBD和CRC队列中确定了Megasphaera的丰富性.
- 研究了M. elsdenii对树突细胞 (DC) 激活和T细胞反应的影响.
- 利用托尔类受体4淘汰赛 (Tlr4-/-) 小鼠来研究这种机制.
- 分析了早期与晚期CRC患者的Megasphaera患病率.
- 采用大肠炎相关癌症小鼠模型 (AOM/DSS).
主要成果:
- 埃尔斯德尼菌通过TLR4/NF-κB/IRF4通路促进DC介导的Th1和Th17炎症.
- 被M. elsdenii殖民的tlr4-/-小鼠显示DC透率降低和T细胞反应受损.
- 在早期发病的CRC患者中,Megasphaera的流行率很高.
- 在小鼠中,M. elsdenii 和丰富的微生物群加剧了结肠炎相关的癌症.
结论:
- 巨,特别是M. elsdenii,在结肠瘤发生中起着致病作用.
- 埃尔斯德尼菌通过TLR4通路激活DCs来诱导炎症.
- 这项研究强调了Megasphaera作为IBD和CRC的潜在治疗点.
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