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肠道调节T细胞的功能障碍和代谢重编程艾滋病毒感染的免疫不响应者

Minrui Yu^1,2, Mengmeng Qu², Zerui Wang³

¹Medical School of Chinese PLA, Beijing 100853, China.

|August 13, 2025

概括

艾滋病毒感染会损害肠道调节T细胞 (Tregs),导致免疫复原失败. 补充短链脂肪酸 (SCFA) 恢复了非反应者的Treg功能和新陈代谢.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
病毒学病毒学

背景情况:

艾滋病毒感染会破坏肠道微环境,影响免疫系统的恒常性.
调节性T细胞 (Tregs) 对肠道平衡至关重要,但它们在与艾滋病毒相关的免疫复合失败中的作用尚不清楚.

研究的目的:

研究艾滋病毒感染个体的肠道Tregs的功能和特征,这些个体具有不同的免疫反应.
探索短链脂肪酸 (SCFA) 对艾滋病毒感染中的Treg功能障碍的影响.

主要方法:

单细胞RNA测序 (scRNA-seq) 用于分析来自HIV阴性对照,免疫反应者和非反应者的肠道Treg种群.
量化了肠道微生物群组成和SCFA水平.
在体外实验中评估了SCFA补充剂对Treg功能和新陈代谢的影响.

主要成果:

免疫不响应者 (INRs) 具有功能障碍的肠道Tregs的比例增加,抑制能力降低,亡增加.
INRs显示Treg代谢重编程,有利于氧化酸化 (OXPHOS) 上的糖解.
在INR中观察到减少的SCFA产生细菌和SCFA水平.

结论:

肠道Treg功能障碍,以代谢重编程和抑制功能受损为特征,有助于艾滋病毒感染个体的免疫复原失败.
补充SCFA可以恢复Treg功能,新陈代谢,并减少亡,突出显示一种潜在的治疗策略.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒这就是SCFAFA.这是Tregs.在这里,我们可以看到子子.免疫学非响应者.免疫反应者免疫反应者

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