安德罗格拉菲斯 (Andrographis paniculata) 提取物通过增强表皮干细胞功能和加强它们的细胞外支来支持皮肤平衡
Roberta Lotti1, Laetitia Cattuzzato2, Xuefeng Huang3
1DermoLAB, Surgical, Medical, Dental and Morphological Sciences Department, University of Modena and Reggio Emilia, 41124 Modena, Italy.
Cells
|August 13, 2025
概括
安德罗格拉菲斯 (Andrographis paniculata) 提取物 (APE) 通过增强皮肤-表皮结,并保留皮细胞干细胞潜力,改善皮肤衰老. 这种天然化合物支持皮肤再生和修复,具有抗衰老的好处.
科学领域:
- 皮肤病学 皮肤病学
- 细胞生物学 细胞生物学
- 自然产品化学 自然产品化学
背景情况:
- 皮肤衰老涉及表皮平衡和皮肤-表皮结 (DEJ) 完整性的降低.
- 减少干细胞潜力和受损的组织再生是老化皮肤的关键特征.
研究的目的:
- 为了研究Andrographis paniculata提取物 (APE) 对人体皮肤中的角质细胞干细胞 (KSC) 和DEJ成分的影响.
- 评估APE作为一种针对干细胞维护和细胞外矩阵稳定性的皮肤抗衰老策略的潜力.
主要方法:
- 利用人类皮肤扩展剂和细胞培养模型来评估APE的影响.
- 分析了DEJ组成标记物 (原IV,拉米宁,MMP-9) 和KSC干性标记物 (原XVII,β1-整体素,Ki-67,KRT15,幸存者,LRIG1).
- 采用了模拟UVB诱导的DEJ损伤的共同培养模型.
主要成果:
- 通过增加原四和胺素,APE增强了DEJ的组成,并减少了MMP-9.
- 通过对相关标记物进行上调,APE保留了KSC的干性潜力.
- APE选择性地刺激了KSC的增殖,并促进了原IV和拉米宁的分泌.
- 在模拟的光损伤条件下,APE增加了KSC中的拉米宁产量.
结论:
- 安德罗格拉菲斯 (Andrographis paniculata) 提取物 (APE) 显示出皮肤抗衰老应用的巨大潜力.
- APE改善了DEJ的完整性,并保持了KSC的茎状,促进了皮肤的再生和修复.
- 通过准关键的细胞和基质组件,APE提供了一种有希望的天然方法来对抗皮肤衰老.
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