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Updated: Sep 11, 2025

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特定的低/内源复制应激反应通过受控的ROS生产以适应的方式保护基因组稳定性,并在转化细胞中受到失调

Bernard S Lopez1

  • 1Université Paris-Cité, INSERM U1016, UMR 8104 CNRS, Institut Cochin, 75014 Paris, France.

Cells
|August 13, 2025
PubMed
概括

细胞利用一种新的低水平压力-DNA损伤反应 (LoL-DDR) 来防止因复制压力而导致的基因组损伤. 这种途径的调节失调通过创建ROS驱动的循环来推动癌症的进展.

关键词:
对DNA损伤的反应反应在 NF-κBB 中.PARP1 的第一部分.这就是ROSOS ROS.遗传不稳定性 遗传不稳定性复制压力是复制的压力.

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