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高压氧气疗法的微血管,生物化学和临床影响在反复性糖尿病足的糖尿病足中

Daniela Martins-Mendes^1,2,3,4, Raquel Costa⁵, Ilda Rodrigues^4,6

¹RISE-Health, School of Medicine and Biomedical Sciences, Fernando Pessoa University, Fernando Pessoa Teaching and Culture Foundation, Avenida Fernando Pessoa 150, 4420-096 Gondomar, Portugal.

|August 13, 2025

概括

高压氧气疗法 (HBOT) 改善了糖尿病足 (DFU) 的伤口愈合和生物标志物概况. 接受HBOT的患者在3年内显示DFU大小减少,截肢率和死亡率降低.

科学领域:

生物医学工程生物医学工程
伤口治愈研究研究伤口治愈研究
糖尿病并发症管理管理管理

背景情况:

糖尿病足 (DFU) 在糖尿病管理中是一个重大挑战,经常表现出不良的愈合.
高压氧气疗法 (HBOT) 是作为辅助治疗的研究,但其长期影响需要进一步阐明.
描述HBOT对系统生物标志物,微血管和DFU临床结果的影响至关重要.

研究的目的:

评估HBOT对全身生物标志物,局部微血管和DFU患者临床结果的长期影响.
在36个月的时间内,评估HBOT作为治疗耐药性缺血性DFU的辅助疗法的疗效.
为了调查炎症和血管原生标志物和微血管密度在HBOT反应中的变化.

主要方法:

一项非随机前性研究,涉及20名患有缺血性DFU的患者,持续36个月.
在接受HBOT加标准护理的14名患者和仅接受标准护理的6名患者之间进行比较.
评估临床结果 (DFU解决,复发,截肢,死亡率),系统生物标志物和伤口特征,包括CD31免疫染对微血管密度.

主要成果:

3个月后,HBOT组的DFU大小和红细胞沉积率显著降低,炎症标志物 (CRP) 和血管生成因子 (VEGF,PlGF) 的改善趋势.
在HBOT组中观察到肌层衍生因子-1α (SDF1-α) 的增加和CD31+微血管密度的明显增加.
接受HBOT治疗的患者的下肢截肢率 (LEA) 和死亡率较低,伤口持续愈合三年;复发率相似.

结论:

在耐治疗性缺血性DFU患者中,HBOT与改善伤口愈合和有利的全身生物标志物概况有关.
这项研究表明,HBOT可能是管理复杂的DFU的有益辅助疗法.
需要进行更大规模的随机对照试验来证实这些发现,并由于研究的小样本大小和非随机设计,建立概括性.

关键词:

血管新生是因为血管新生.糖尿病糖尿病患者糖尿病患者糖尿病患者的糖尿病脚足部足部足部足部足部足部高压氧气疗法 (hyperbaric oxygen therapy) 是一种高压氧气疗法.微型血管密度的密度

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