神经母细胞瘤中的微生物组:在瘤微生物组世界中的一个处女岛
Ashwath Keshav Giri1, Poorvi Subramanian1, Loganayaki Periyasamy1
1Department of Physiological Science, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
Cells
|August 13, 2025
概括
肠道微生物群影响神经母细胞瘤 (NB) 风险,发展和治疗结果. 了解这些微生物相互作用为这种婴儿癌症提供了新的治疗策略.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 肠道微生物群在各种癌症中起着至关重要的作用,影响癌症发生,进展和治疗反应.
- 关于微生物组在神经母细胞瘤 (NB),一种常见的婴儿癌症中的作用的证据是有限的和碎片化的.
研究的目的:
- 审查微生物群在人类健康和癌症中的组成,多样性和意义.
- 阐明肠道和瘤微生物群的功能相关性和临床意义,特别是针对神经母细胞瘤.
主要方法:
- 关于人类健康和各种癌症中的微生物群的综合文献综述.
- 在神经母细胞瘤模型中研究肠道微生物组的临床和临床前研究的分析.
主要成果:
- 肠道微生物群的组成预测了NB风险和治疗结果.
- 在NB发育过程中观察到微生物组的变化,并影响病变发生.
- 瘤透微生物群的组成也预测了NB患者的结果.
结论:
- 肠道和瘤微生物组在神经母细胞瘤中具有功能相关性和临床意义.
- 微生物组调节,包括益生菌干预措施,显示出稳定NB相关微生物失调的潜力.
- 准微生物组是新型神经母细胞瘤疗法的一个有希望的途径.
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