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通过EGFR指导研究对向共价抑制剂进行分析和优化

Tahereh Damghani1, Surbhi P Chitnis1, Omobolanle A Abidakun1

  • 1Department of Chemistry, The State University of New York at Buffalo, Buffalo, New York 14260, United States.

Journal of medicinal chemistry
|August 13, 2025
PubMed
概括

向共价抑制剂 (TCI) 在药物发现方面表现有前途. 优化TCI涉及到平衡失活效率和选择性,而不仅仅是最大化速度,以获得更好的临床结果.

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