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综合FAPI-42 PET/MR提高了乳腺癌的诊断准确性:与同时获得的乳腺MRI进行比较

Peng Hou^1,2, Jie Lv², Weige Tan³

¹Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan 2nd Road, Guangzhou, 510080, China.

European journal of nuclear medicine and molecular imaging

|August 13, 2025

概括

-18标记纤维细胞激活蛋白抑制剂42 (18F]FAPI-42) PET/MR通过减少假阳性和改善淋巴结转移检测与标准乳腺MRI相比,显著提高了乳腺癌诊断. 这种先进的成像技术提供了更准确的分期,特别是在具有挑战性的病变.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学是一种核医学.
医疗成像医学成像

背景情况:

准确的诊断和乳腺癌的分期对于有效的治疗计划至关重要.
目前的乳腺MRI诊断性能存在局限性,特别是在区分良性病变和恶性病变以及评估状淋巴结参与方面.
纤维细胞激活蛋白 (FAPI) 向的PET成像显示出癌症检测的希望,这是由于FAP在瘤相关纤维细胞中的过度表达.

研究的目的:

为了评估-18标记纤维细胞激活蛋白抑制剂42 ([18F]FAPI-42) PET/MR与标准乳腺MRI相比的诊断疗效.
评估[18F]FAPI-42 PET/MR在识别原发性乳腺病变和检测状淋巴结转移方面的能力.
为了确定是否集成的[18F]FAPI-42 PET/MR提供了比单独的乳腺MRI更好的诊断准确性,特异性和灵敏性.

主要方法:

64名患有BI-RADS 4或5型乳腺病变的妇女的前性研究.
所有参与者都接受了对比度增强的[18F]FAPI PET/MRI扫描.
用接收器操作特征 (ROC) 分析和净重新分类改进 (NRI) 来评估诊断性能,其中组织学和随访作为黄金标准.

主要成果:

集成的[18F]FAPI-42 PET/MR 对于原发性乳腺病变的乳房MRI (68%) 与乳房MRI (96%) 相比显示出更高的特异性,显著减少了假阳性.
对于状淋巴结的评估,[18F]FAPI-42 PET/MR显示提高了灵敏度 (95%) 与乳房MRI (62%) 相比.
[18F]FAPI-42 PET/MR显著提高了BI-RADS 4病变的诊断准确性,并提高了小病变 (<10毫米) 的特异性.

结论:

[18F]FAPI-42 PET/MR与传统的乳腺MRI相比,显著提高了乳腺癌检测和分期的诊断准确性.
这种模式在减少虚假阳性发现和改善带淋巴结转移的检测方面表现出色.
[18F]FAPI-42 PET/MR显示出精细化乳腺癌诊断的巨大潜力,特别是在BI-RADS 4病变和小瘤方面.

关键词:

乳腺癌是什么? 乳腺癌是什么诊断的准确性诊断的准确性纤维细胞激活蛋白抑制剂纤维细胞激活蛋白抑制剂分子成像学分子成像学聚乙烯 (PET) /MR (MR) 是一种

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