普拉默-文森综合征:一个回顾性多中心研究
Ahmed Elsayed Alzamzamy1,2, Mohammed Tag-Adeen3, Abdullah Zuhair Alyouzbaki4
1Department of Gastroenterology and Hepatology, Military Medical Academy, Cairo, Egypt.
Digestive diseases and sciences
|August 13, 2025
概括
普拉默-文森综合征 (PVS) 主要影响中年女性,与缺铁性贫血 (IDA) 有关. 内镜扩张是PVS的有效治疗方法,通常只需要一次会议.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 在瘤学瘤学.
背景情况:
- 普拉默-文森综合征 (PVS) 是一种罕见的疾病,其特征是食不全,缺铁性贫血 (IDA) 和上管网.
- PVS与食道状细胞癌 (SCC) 的风险增加有关.
- 关于PVS的综合特征和管理的数据有限.
研究的目的:
- 分析普拉默-文森综合征的人口和临床特征.
- 评估多个中心的PVS成像发现和治疗结果.
- 评估PVS患者恶性转变的风险.
主要方法:
- 在七个三级肠道内镜中心进行了一项回顾性多中心研究.
- 对2021年至2024年期间被诊断患有PVS的56名患者的医疗记录进行了审查.
- 分析的数据包括临床表现,实验室结果,成像和治疗方式.
主要成果:
- 这项研究包括56名患有PVS的患者 (80.5%为女性,平均年龄为41岁),所有患者都表现出缺食症和IDA.
- 内镜扩张,主要使用Savary-Gilliard布吉扩张器,是主要的治疗方法,76.8%的患者对单次治疗有反应.
- 在随访期间,很少有百分比 (7.1%) 患有食道SCC/食道形,没有显著的扩张后并发症.
结论:
- 普拉默-文森综合征主要影响中年女性,并与IDA密切相关.
- 内镜扩张是一种有效和安全的PVS治疗方法,通常需要一次干预.
- 在PVS患者中,由于食道SCC的风险,对恶性转变的密切监测至关重要.
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