泌尿酸酶类型的塑原激活基因Pro141Leu多态和前列腺癌患者之间的关系
Cemil Gülüm1, Pelin Eroğlu1, Rojda Tanrıverdi2
1Mersin University, Faculty of Science, Department of Chemistry - Mersin, Turkey.
概括
这项研究研究了泌尿酸酶类型的塑原激活剂 (uPA) 基因Pro141Leu在前列腺癌中的多态性. 没有发现Pro141Leu多态性是前列腺癌发展的显著遗传风险因素.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 前列腺癌的遗传学仍然不完全理解,许多病例缺乏已知的遗传贡献者.
- 泌尿酸酶类型的塑原激活剂 (uPA) 基因与癌症侵袭和转移有关.
- uPA基因的Pro141Leu多态性是一种潜在的,但尚未被证明的前列腺癌发展因素.
研究的目的:
- 调查尿激酶类型等离子体激活剂 (uPA) 基因Pro141Leu多态化与前列腺癌风险之间的关联.
- 为了确定rs2227564多态是否是前列腺癌的遗传风险因素.
主要方法:
- 实时聚合酶连锁反应 (PCR) TaqMan测试用于在前列腺癌患者和健康对照中确定uPA Pro141Leu多态的基因型.
- 与酶相关的免疫吸收试验 (ELISA) 用于测量uPA,尿素酶类型等离子体激活受体 (uPAR) 和前列腺特异性抗原 (PSA) 水平.
主要成果:
- 在前列腺癌患者和对照组之间没有观察到基因型分布 (CC,CT,TT) 的显著差异.
- 泌尿酸酶类型等离子体激活剂 (uPA) 基因Pro141Leu多态性没有与前列腺癌风险相关.
结论:
- 这是第一次研究rs2227564多态与前列腺癌的关联.
- 研究结果表明,尿激酶类型等离子体激活剂 (uPA) 基因Pro141Leu多态性并不是前列腺癌的显著遗传风险因素.
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