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Updated: Sep 11, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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针对CDK2进行癌症治疗.

Erik S Knudsen1, Agnieszka K Witkiewicz2, Ioannis Sanidas3

  • 1Department of Molecular and Cellular Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA.

Cell reports
|August 13, 2025
PubMed
概括

向循环素依赖性激酶2 (CDK2) 提供了一个复杂但有前途的癌症治疗策略. 瘤遗传学和像环林E这样的生物标志物指导CDK2抑制剂的有效性和组合疗法.

关键词:
这是一种CDK抑制剂.在CDK2中使用CDK2.在CDK4/6中使用.这就是CDKN2A.CP: 癌症 癌症 癌症在 RB RB RB 的位置上.细胞循环中的细胞循环.环 D1 D1 的时间.环林E 环林E 环林p16IN4AA的使用情况

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