葡萄糖代谢及其后果是否取决于阻塞性睡眠呼吸暂停的表型?
Akeruetai Suwannakin1,2, Sirimon Reutrakul3,4, Naricha Chirakalwasan1,2
1Division of Pulmonary and Critical care medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University.
Current opinion in pulmonary medicine
|August 13, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与血糖控制不良和心脏病有关. 针对特定OSA类型和代谢生物标志物的个性化治疗可能会改善患者的治疗结果.
科学领域:
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
- 心脏病学 心脏病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种与代谢功能障碍相关的普遍睡眠障碍.
- 越来越多的证据将OSA与葡萄糖代谢异常联系起来,包括胰岛素抵抗和2型糖尿病.
- OSA也因其与心血管疾病的关联而得到认可.
研究的目的:
- 审查OSA和葡萄糖代谢之间的复杂关系.
- 检查OSA对心血管结果的影响.
- 为了探索与同时存在的OSA和葡萄糖失调患者的潜在治疗策略.
主要方法:
- 对研究OSA,葡萄糖代谢和心血管结果的文献综述.
- 对OSA表型及其代谢影响的现有证据的分析.
- 持续正气道 (CPAP) 治疗和生活方式改变的有效性评估.
主要成果:
- OSA是异常葡萄糖代谢和心血管疾病的重要危险因素.
- 在OSA和葡萄糖失调之间存在双向关系,包括2型糖尿病.
- 特定的OSA表型 (例如,REM相关的OSA) 与较差的血糖控制有关.
- 持续的正气道压力 (CPAP) 治疗对葡萄糖平衡有不一致的影响.
- 减肥干预措施可以改善糖尿病患者的OSA和血糖控制.
结论:
- 针对特定OSA表型的个性化治疗策略对于改善代谢结果至关重要.
- 整合代谢生物标志物可以帮助早期检测和指导精确干预.
- 需要进一步的研究来优化对OSA和葡萄糖失调患者的管理.
相关概念视频
Sleep Apnea
220
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
220
Overview of Carbohydrate Metabolism
1.8K
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
1.8K
Glucose Transporters
24.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
24.1K
Glucose Homeostasis: Regulation of Blood Glucose
2.5K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
2.5K
Diabetes: Symptoms, Diagnosis, and Complications
692
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
692
Carbohydrate Metabolism
11.7K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.7K


