固定稳定对精神分裂症临床阶段和转换的预测作用及其与认知功能的相关性
Yuqing Gu1, Yu Li1,2, Lihua Xu1
1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Xu hui, Shanghai 200030, China.
Schizophrenia bulletin
|August 13, 2025
概括
固定不稳定随着精神分裂症的进展而恶化,并与认知能力下降有关. 双变轮圆形面积 (BCEA) 显示了作为预测精神病转换的生物标志物的潜力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 固定稳定与认知功能密切相关.
- 精神分裂症涉及渐进的认知障碍和可能转化为精神病.
研究的目的:
- 研究不同阶段的精神分裂症患者的固定稳定性.
- 检查固定稳定性和认知障碍之间的关系.
- 确定固定稳定性对精神病转换的预测作用.
主要方法:
- 使用双变形轮圆面积 (BCEA) 测量固定稳定性.
- 使用测量和治疗研究来改善精神分裂症认知 (MATRICS) 评估认知.共识认知电池.
- 研究了75名第一发精神分裂症 (FES) 患者,75名临床高风险综合征 (CHR) 患者和75名健康对照 (HC).
- 进行了一年的纵向研究,使用后勤和考克斯回归模型进行诊断和转化预测.
主要成果:
- 与HC相比,患者的固定不稳定性和认知障碍增加,从CHR恶化到FES.
- 在CHR中,BCEA与认知得分有负相关性;这在FES中没有观察到.
- 一个诊断模型区分HC和FES,AUC为0.914.
- 在66个CHR中,有13个转换 (19.70%);在小BCEA组 (27.27%) 和大BCEA组 (12.12%) 中,转换率更高.
- 转换预测模型实现了0.708 AUC.
结论:
- 固定不稳定性与精神分裂症进展,并与认知缺陷有关.
- BCEA可以作为一个有价值的生物标志物来预测转化为精神病.
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