对近更年期妇女生化标志物的基于人口和个性化的参考间隔进行比较分析:来自PALM队列研究的人口
Jiaming Wu1,2, Penghui Feng3, Jinming Zhang1,2
1National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing, China.
个性化参考间隔 (prRI) 改善了更年期期间生化标志物的解释. 传统的基于人口的参考间隔 (popRIs) 具有有限的实用性,特别是对于高生物变异的绝经过渡期妇女来说.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 更年期与显著的生化标记物变化有关.
- 传统的基于人口的参考间隔 (popRIs) 可能不准确地反映绝经妇女的个体变化.
- 这限制了在这个生命阶段对生物化学测试的临床解释.
研究的目的:
- 为更年期妇女建立个性化参考间隔 (prRI).
- 为了比较prRI与传统popRI的临床实用性.
主要方法:
- 对来自PALM队列的899名女性 (年龄在35-64岁之间) 在生殖,更年期过渡和更年期后阶段的分析.
- 评估了13个生化标志物,其中6个基于统计学意义和随机森林模型重要性而被选择.
- 计算生物变异 (BV),总变异 (TV),个性指数 (II) 和参考区间指数 (RII) 以比较popRIs和prRIs.
主要成果:
- ALT,TG和FSH在更年期的不同阶段显示出显著的差异,是关键预测因素.
- 对于这些标记物,观察到很高的生物变异性,popRI的效用有限,RII值中位数低于1.0.0,表明popRI的效用有限.
- 在更年期过渡的90%以上的女性中,FSH表现出RII<0.5,突出显示出popRI适用性较差.
结论:
- 将popRIs与prRIs结合起来,可以提高更年期过渡妇女高BV的生化标志物解释.
- 对于prRIs的广泛临床采用,需要在更大,更多样化的队列中进一步验证.
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