在喀麦隆德的废水中对肝炎E病毒的分子监测
Dowbiss Meta-Djomsi1,2, Marie Atsama-Amougou1,3, Modeste Romuald Ngamaleu1,4,5
1Centre de Recherche sur les Maladies Émergentes et Re-Emergentes, Yaounde, Cameroon.
PloS one
|August 13, 2025
概括
甲型肝炎病毒 (HEV) 已在德的废水中检测到,HEV-C1菌株表明动物传播. 这突显了环境和食品带来的风险,强调了对公共卫生的废水监测.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 动物传染病监测监测动物传染病.
背景情况:
- 肝炎E病毒 (HEV) 是一种通过撒哈拉以南非洲的污染食物/水传播的动物性病原体.
- 环境监测对于了解HEV传输动态至关重要.
研究的目的:
- 为了评估环境废水中HEV的流行率和分子特征,在喀麦隆的德,喀麦隆.
- 确定城市环境中HEV的潜在来源和传播途径.
主要方法:
- 基于社区的监测使用来自不同城市场所的每月未经处理的废水样本 (2023年1月至12月).
- 来自开放阅读框架1区域的HEV序列的分子遗传学分析.
主要成果:
- 在26.4%的废水样本中检测到HEV,在住宅区 (41.7%) 和植物灌点的流行率更高.
- 在干旱季节,检测率显著上升.
- 遗传学分析揭示了与动物相关的Orthohepevirus C基因型C1密切相关的HEV菌株.
结论:
- 这项研究是首次报告雅德废水中HEV检测和遗传分析.
- 在废水中广泛的HEV循环表明潜在的环境和食品传播风险.
- 类似HEV-C1菌株的存在表明动物在城市HEV传播中可能发挥作用,需要一种"健康"的方法.
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