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Updated: Sep 11, 2025

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
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Published on: August 25, 2023

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实体CRISPR瘤发生和多原子分析揭示了MPNST中酸通路中断的脆弱性

Gavin R McGivney1,2,3, Qierra R Brockman1,2,4, Nicholas Borcherding5

  • 1Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52240, USA.

Science advances
|August 13, 2025
PubMed
概括

带有CDKN2A损失的恶性外周神经膜瘤 (MPNSTs) 依赖酸通路 (PPP) 进行生长. 向葡萄糖-6-酸脱酶 (G6PD) 或NRF2显示出治疗这些侵袭性癌症的前景.

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