在使用多层链图的猪中,Campylobacter coli对化诺和化物耐药性的危险因素
Christine A Wang1, William J Love1, Manuel Jara1
1Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America.
PLoS computational biology
|August 13, 2025
概括
猪中的耐药坎皮洛巴克特菌对公众健康构成风险. 除了遗传因素外,重金属暴露在传统和无抗生素系统中显著导致化和化物耐药性.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗生素耐药性的流行病学
- 一个健康,一个健康.
背景情况:
- 在Campylobacter spp.中的抗菌耐药性 (AMR). 是一个重要的全球公共卫生问题.
- 之前对坎皮洛巴克特抗菌药物耐药性风险因素的研究主要集中在农场级抗菌剂的使用上.
- 了解更广泛的风险因素对于有效的控制策略至关重要,特别是在各种生产系统中.
研究的目的:
- 识别和量化与Campylobacter coli中化和化物耐药性相关的风险因素.
- 为了比较传统和无抗生素 (ABF) 猪生产系统的风险因素.
- 在AMR流行病学中利用链图模型进行因果发现.
主要方法:
- 来自1082种Campylobacter coli分离物的基因型和抗微生物敏感性数据的分析.
- 整合了来自14个猪群调查的宿主暴露数据.
- 应用链图模型来量化风险因素对最小抑制度 (MIC) 的贡献.
主要成果:
- 吉尔A T86I点突变是诺基诺隆耐药性的主要决定因素,解释了西普洛素MIC的58-79%的变异.
- 遗传因素和宿主暴露都对宏类抗药性 (亚齐胺,红胺) 产生了显著的贡献.
- 暴露在重金属中成为常规和ABF猪系统中耐药性的一致风险因素.
结论:
- 链图模型为AMR复杂的流行病学提供了宝贵的见解.
- 特定环境的风险因素,包括重金属暴露,在坎皮洛巴克特耐药性方面发挥着关键作用.
- 这种方法有助于因果发现,并可为针对性干预提供信息,以减轻AMR的传播.
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