产前压力,社会经济地位和婴儿表观遗传衰老之间的联系
Jessica F Sperber1, Emma R Hart1, Sonya V Troller-Renfree1
1Teachers College, Columbia University, United States of America.
Psychoneuroendocrinology
|August 13, 2025
概括
产前压力和社会经济劣势并没有一致地加速婴儿的表观遗传衰老. 需要进一步的研究来理解这些复杂的发育关系.
科学领域:
- 发育表观遗传学 发育表观遗传学
- 儿科卫生健康 儿科卫生健康
- 健康的社会经济决定因素
背景情况:
- 表观遗传衰老,生物年龄的衡量标准,可能会受到生命早期暴露的影响.
- 产前压力和社会经济劣势是影响儿童发展的关键因素.
研究的目的:
- 调查产前压力和社会经济劣势与婴儿表观遗传衰老之间的联系.
- 检查母亲感知压力,生理压力和家庭社会经济地位对婴儿表观遗传年龄的影响.
主要方法:
- 在怀孕晚期招募了多样化的母亲样本.
- 收集了关于收入,教育,感知压力的母亲调查,以及皮质醇的头发样本.
- 评估婴儿的表观遗传年龄,使用从唾液DNA甲基化数据 (n=159) 中建立的五个表观遗传时钟进行评估.
主要成果:
- 在产前压力或社会经济因素与婴儿表观遗传衰老之间没有发现一致的关联.
- 效应大小与以前的研究进行了比较,并考虑了表观遗传钟在婴儿中的适用性.
结论:
- 该研究没有发现证据支持假设产前压力和社会经济劣势加速1个月大的婴儿的表观遗传衰老.
- 家庭收入,教育和压力对婴儿发育的复杂和潜在不同的影响需要进一步研究.
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