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Updated: Sep 11, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

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鉴定和优化结构-活性关系的dibromoacetophenones作为新型的mIDH1抑制剂

Cong Li1, Min Yang1, Zhiying Cui1

  • 1School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.

European journal of medicinal chemistry
|August 13, 2025
PubMed
概括

研究人员开发了一种新型的双重抑制剂,针对癌症中常见的异酸脱酶1 (IDH1) 突变. 这种化合物,27j,表现出强大的IDH1和PDK1的抑制,减少瘤细胞的增殖和2-基酸盐的产生.

关键词:
异酸脱酶 1 异酸脱酶 1皮鲁酸盐脱酶激酶酶是什么结构 - 活动关系研究 结构 - 活动关系研究

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Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
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