益生菌对2型糖尿病的作用机制:发展和并发症
Duygu Ağagündüz1, Elif Çelik2, Özge Cemali3
1Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara, Türkiye.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|August 13, 2025
概括
益生菌可以通过改善肠道健康和恢复微生物平衡来帮助管理2型糖尿病 (T2DM). 这些有益的细菌影响葡萄糖代谢,减少炎症,可能减轻T2DM的发展和并发症.
科学领域:
- 微生物学 微生物学
- 代谢障碍 代谢障碍 代谢障碍
- 胃肠病学 胃肠病学
背景情况:
- 2型糖尿病 (T2DM) 的特点是高血糖,胰岛素抵抗和炎症.
- 肠道微生物群失生症越来越多地被认为是T2DM病原体中的作用,影响肠道屏障功能和全身炎症.
- 肠道细菌的不平衡导致胰岛素抵抗和葡萄糖代谢受损.
研究的目的:
- 研究益生菌与肠道微生物群和与T2DM有关的宿主信号通路相互作用的机制.
- 提供益生菌,T2DM及其并发症之间的关系的全面概述.
- 探索益生菌作为T2DM治疗调节剂的潜力.
主要方法:
- 对相关文献进行系统审查.
- 在科学数据库中搜索有关益生菌和T2DM的文章.
- 对详细介绍益生菌对肠道微生物群和宿主代谢作用机制的研究进行分析.
主要成果:
- 益生菌在调节肠道微生物群,恢复平衡和增强肠道屏障完整性方面显示出潜力.
- 益生菌可以通过对肠道微生物群和宿主新陈代谢的多种影响,积极影响葡萄糖平衡.
- 机制包括产生有益的代谢物,抑制α-葡萄糖酶,增加短链脂肪酸 (SCFA),抑制病原体和调节神经递质.
结论:
- 益生菌是通过向肠道微生物群来管理T2DM的一个有希望的策略.
- 通过恢复微生物平衡和改善肠道功能,益生菌可以缓解T2DM的关键病理机制.
- 对益生菌干预的进一步研究可能为T2DM及其并发症提供新的治疗途径.
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