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全基因组关联研究和基于生殖特征的母猪弹性基因组预测

L Shi¹, W Hao², Z Li²

¹State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Animal : an international journal of animal bioscience

|August 13, 2025

概括

这项研究介绍了生殖特征的环境标准偏差 (SD_e) 作为猪弹性的一种新测量方法. 子重量和生存率等关键指标SD_e可以增强强壮的猪种群的育种计划.

科学领域:

动物科学动物科学
遗传学遗传学是一个
生殖生物学生殖生物学

背景情况:

动物的性,以降低疾病易感性和药物需求为特征,对于高效的畜牧业生产至关重要.
环境的变化对动物的生殖特征产生了重大影响,影响了它们的适应能力.
使用生殖特征的变化来评估猪的弹性仍然是一个未被充分探索的领域.

研究的目的:

根据生殖特征的环境标准偏差 (SD_e) 开发和验证新的母猪弹性指标.
调查不同猪品种中这些弹性指标的遗传性和基因组基础.
评估这些指标在基因组选择和融入育种计划中的潜力.

主要方法:

收集了来自11321只约克郡母猪,3317只兰德雷斯母猪和1745只杜洛克母猪的纵向生殖数据.
计算各种生殖特征的环境标准偏差 (SD_e) 作为弹性指标.
进行了46358个SNP和9171个基因型个体的全基因组关联研究 (GWAS).
使用BLUP,GBLUP和ssGBLUP方法估计的繁殖值和评估的基因组预测可靠性.

主要成果:

弹性特征的遗传性在各种品种中从0.02到0.61不等.
GWAS确定了130个显著的SNP和3,259个与生殖特征SD_e相关的候选基因.
基因组预测可靠性显示,GBLUP和ssGBLUP的平均增加为0.02-0.04.
子体重和生存率的SD_e被确定为所有三种品种的强有力的弹性指标.

结论:

子体重和生存率的SD_e是适用于约克郡,兰德雷斯和杜洛克母猪的可靠的弹性指标.
特定的SD_e特征 (例如,木乃伊数量,出生弱,死胎,出生健康) 可以用于特定品种的弹性选择.
将这些弹性指标整合到养殖策略中可以提高母猪的生殖性能和抗病能力,为更强壮的猪种群奠定基础.

关键词:

遗传参数估计的估计.基因组选择基因组选择突变和基因的发生生殖性表现的生殖性表现.播种弹性播种弹性

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