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Updated: Sep 11, 2025

Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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克隆型丰富的体态突变驱动了针对封闭的萨尔贝科病毒表位体的公共人类抗体的亲和力成熟

Vishal N Rao1, Iden A Sapse2, Hallie Cohn3

  • 1Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Cell reports
|August 13, 2025
PubMed
概括

公共抗体对于疫苗开发至关重要. 研究人员发现,公共抗体克隆类型中的特定突变 (SHM) 增强了与保存表位素的结合,指导了更好的疫苗设计以保护病原体.

关键词:
CP: 免疫学 免疫学萨尔贝科病毒是一种病毒.亲缘关系成熟的成熟.抗体克隆型 抗体克隆型中央接口的标志性特征低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.蛋白质结构 蛋白质结构公众的抗体.身体上的超突变.

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