产前热量和空气污染暴露改变孕激素和儿童行为:一项纵向研究
Yoko Nomura1, Sameera Ramjan2, Alice Zhiyue Wang3
1Queens College, CUNY, Department of Psychology, Flushing, NY, USA; CUNY Graduate Center, New York, NY, USA; Icahn School of Medicine at Mount Sinai Department of Psychiatry, New York, NY, USA; Icahn School of Medicine at Mount Sinai Department of Environmental Medicine, New York, NY, USA; CUNY Advanced Sciences Research Center, New York, NY, USA.
产前热量和空气污染暴露相互作用,影响孩子的行为,由孕激素水平介导. 这些环境因素的结合可能会增加儿童行为困难的风险.
科学领域:
- 环境健康 环境健康
- 发展心理学 发展心理学
- 内分泌学 在内分泌学.
背景情况:
- 产前暴露于热量与童年行为问题有关.
- 内分泌机制和空气污染的作用尚不清楚.
- 了解这些相互作用对于公共卫生至关重要.
研究的目的:
- 检查热气污染对儿童行为的相互作用.
- 调查孕激素作为潜在的调解者.
- 在纽约市多元化的出生队列中评估影响.
主要方法:
- 评估了三个月的特定热量暴露和空气污染 (NO2,PM2.5).
- 在3岁时测量了头发的孕激素水平.
- 在4-5岁时评估了儿童的行为 (内部化/外部化).
- 使用多组结构方程建模.
主要成果:
- 在孕激素水平上,产前热量和空气污染之间的显著相互作用.
- 在高污染地区,第一季度的热量暴露增加了孕激素,与增加的内化和外化行为有关.
- 在低污染地区没有观察到影响.
- 在高污染地区,晚期三月份的热量暴露显示出剂量-反应孕激素减少.
结论:
- 孕激素可能会调解产前环境暴露与儿童行为之间的联系.
- 空气污染可能会放大热量对行为的影响.
- 这些发现支持健康和疾病的发育起源框架,突出了脆弱社区的干预需求.
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