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牛乳酸在调节肠道血清系统中的保护作用:对肠道炎症的影响
Berta Buey1, Inés Abad2, Andrea Bellés1
1Departamento de Farmacología, Fisiología y Medicina Legal y Forense. Facultad de Veterinaria. Universidad de Zaragoza. Zaragoza, Spain; Instituto Agroalimentario de Aragón (IA2). Universidad de Zaragoza-CITA. Zaragoza, Spain.
牛乳酸 (bLf) 调节了肠道.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 肠道的血清系统对肠道平衡至关重要,其失调与炎症性肠道疾病 (IBD) 相关.
- 血清素 (5-HT) 信号影响肠道功能,免疫反应和肠-大脑轴.
- 牛乳酸 (bLf) 是一种乳糖蛋白,具有已知的与胃肠道健康相关的生物活性.
研究的目的:
- 为了研究bLf对肠道血清系统的调节作用.
- 评估bLf对肠道炎症和恒温的影响.
- 评估bLf作为肠道健康的功能性食品成分的潜力.
主要方法:
- 使用Caco-2/TC7细胞进行体外研究,以评估bLf对血清素载体 (SERT) 和血清素受体 (5-HTRs) 的影响.
- 在小鼠体内研究,包括口服BLF和硫酸 (DSS) 诱导的大肠炎模型.
- 在肠道组织中分析mRNA表达关键血清系统成分 (SERT,TPH1,TPH2,5-HTRs) 的水平.
主要成果:
- 在体外,bLf增强了SERT活性和mRNA表达,并在Caco-2/TC7细胞中调节了5-HTR mRNA水平.
- 在小鼠中,口服bLf上调了SERT,基酶2 (TPH2) 和5-HTRmRNA在阴茎中的表达.
- 在DSS诱导的大肠炎中,bLf减弱了炎症,并在结肠中使SERT,TPH1,TPH2和5-HTRmRNA的表达正常化.
结论:
- 牛乳酸在生理和炎症状态下有效调节肠道血清系统的关键组成部分.
- bLf通过影响血清激素信号通路,显示出在控制肠道炎症方面的潜力.
- bLf是一种有前途的功能性食品成分,用于针对肠道疾病的营养策略,并支持肠-大脑轴功能.
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