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TRPM6和TRPM7遗传多态,食,血,以及妊娠期糖尿病

Xiyu Cao¹, Huaqi Zhang¹, Jin Liu¹

¹Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

The Journal of nutritional biochemistry

|August 13, 2025

概括

在TRPM6和TRPM7的遗传变异影响的吸收和妊娠期糖尿病 (GDM) 的风险. 不足够的摄入量会加剧这种风险,特别是在基因突变较少的女性中.

科学领域:

遗传学是一个遗传学.
营养科学营养科学
生殖健康生殖健康

背景情况:

在TRPM6和TRPM7中的遗传变异与 (Mg) 吸收有关.
孕期糖尿病 (GDM) 是一个重要的妊娠并发症.
平衡在葡萄糖代谢中起作用.

研究的目的:

调查摄入Mg和TRPM6/TRPM7基因多态化对血Mg水平的综合影响.
确定这些因素与GDM风险之间的关联.
探索遗传变异和饮食中的Mg与GDM发病率之间的潜在相互作用.

主要方法:

在1323名孕妇中进行TRPM6 (rs2274924,rs3750425) 和TRPM7 (rs8042919) 单核酸多态 (SNP) 的基因定型.
使用食物频率调查问卷评估饮食中的Mg摄入量.
通过口服葡萄糖耐受性测试测量血Mg度和诊断GDM.

主要成果:

在TRPM6/TRPM7中更高数量的突变等位基因与GDM风险增加有关 (RR=1.65).
观察到基因变异和Mg摄入量与GDM风险之间的显著相互作用 (P=.039).
不足够的Mg摄入量 (<370.0 mg/d) 降低了血Mg和增加了GDM发生率,特别是在具有较少突变等位基因的女性中 (RR=2.14).

结论:

TRPM6/TRPM7基因变异影响GDM风险.
饮食中摄入的Mg显著调节了这些基因变异对GDM风险的影响.
足够的摄入量可能对减轻孕妇GDM风险至关重要,特别是那些具有特定TRPM6/TRPM7基因型的孕妇.

关键词:

临床营养学临床营养学基因-营养物相互作用孕期糖尿病孕期糖尿病的摄入量的摄入量血中的度是如何形成的怀孕健康怀孕健康

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