用多酶抑制剂治疗局部先进的分化甲状腺癌的新辅助疗法:系统性审查
Justin Bauzon1, Guillermo Ponce de Leon-Ballesteros2,3, Eddy Lincango4
1Department of Endocrine Surgery, Cleveland Clinic, Cleveland, Ohio, USA.
Thyroid : official journal of the American Thyroid Association
|August 13, 2025
概括
新辅助性多酶抑制剂 (MKIs) 可能改善晚期分化甲状腺癌 (DTC) 的外科切除率. 需要进一步的前性研究来证实这些发现,因为证据质量不佳.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
背景情况:
- 多酶抑制剂 (MKIs) 已被确立用于治疗晚期甲状腺癌.
- 新辅助性MKI已被建议用于局部晚期分化甲状腺癌 (DTC).
研究的目的:
- 对局部先进的DTC中新辅助MKI的现有研究进行审查.
- 评估新辅助性MKI对手术和瘤结局的影响.
主要方法:
- 在四个数据库 (PubMed,Cochrane,Scopus,EMBASE) 进行系统的文献搜索.
- 包括观察性研究和前性II期试验.
- 对接受新辅助MKI的患者的瘤反应和手术结果的分析.
主要成果:
- 分析了来自23项研究的119名参与者;伦瓦提尼布和索拉芬尼布是常见的MKI.
- 观察到显著的瘤体积减少 (25-87%) 和部分反应率 (33.3-76.9%).
- 新辅助性MKI能够在83.3%的最初无法手术或高风险瘤患者中进行手术.
结论:
- 新辅助性MKI显示出改善局部发达DTC的切除率的潜力.
- 目前的证据质量很低,需要进一步的前性研究.
- 确认新辅助MKI的益处需要强大的临床试验.
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