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运动干预对接受化疗的乳腺癌患者心脏毒性的影响:准随机对照试验的研究方案
Ran Wei1, Yingjie Cai1, Yufei Guo1
1Department of Nursing, First Affiliated Hospital of Dalian Medical University, Dalian, China.
BMJ open
|August 13, 2025
概括
这项研究研究了基于健康行动过程方法 (HAPA) 模型的运动干预措施,以预防接受化疗的乳腺癌患者的心脏毒性. 哈帕模型改善了身体活动,自我效能,社会支持和坚持,降低了心脏毒性风险.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 行为科学 行为科学
背景情况:
- 接受抗瘤治疗的乳腺癌 (BC) 患者面临心脏毒性风险增加,这是主要的非癌症死亡原因.
- 低体力活动水平在BC患者中很常见,阻碍心脏毒性预防.
- 卫生行动过程方法 (HAPA) 模型在促进炼坚持方面显示出前景.
研究的目的:
- 评估基于HAPA模型的运动干预措施对化学治疗期间BC患者心脏毒性指标的影响.
- 为了提高身体活动水平,练习自我效能,社会支持,并在BC患者中练习合规.
- 减轻心脏毒性并改善BC幸存者的生活质量.
主要方法:
- 一项半随机对照试验,在4个月的干预期内,涉及62名BC患者.
- 干预组接受了基于HAPA模型的运动指导;对照组接受了标准指导.
- 主要结局:心脏毒性发生率 (ECG). 二次结果:身体活动 (IPAQ-SF),自我效能 (SEE),社会支持 (SSSE) 和炼合规性.
主要成果:
- 与标准指导相比,基于HAPA模型的干预预计将减少心脏毒性发生率.
- 在干预组中,预计身体活动水平,炼自我效能,社会支持和炼合规性会有显著的改善.
- 统计分析包括千平方测试,曼-惠特尼U测试和重复测量ANOVA.
结论:
- 基于HAPA模型的运动干预可以有效地预防乳腺癌患者的心脏毒性.
- 这些干预措施改善了影响炼坚持和患者结果的关键因素.
- 这种方法为管理心脏毒性和增强BC患者的身体健康提供了可行的策略.
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