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成功的活体捐赠者肝脏移植从捐赠者与低威尔布兰德因子活动:一个案例报告

Takahiko Omameuda¹, Taiichi Wakiya¹, Yasunaru Sakuma¹

¹Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University, Shimotsuke city, Tochigi, Japan.

Transplantation proceedings

|August 13, 2025

概括

活体捐赠者的肝移植是安全的,即使捐赠者具有低威尔布兰德因子 (VWF) 活性. 仔细的术后管理确保了供体安全和接受者的稳定血静,影响了供体资格标准.

科学领域:

肝病学肝病学是一种肝病学.
移植手术移植手术
血液学血液学血液学

背景情况:

由于安全问题,具有威尔布兰德因子 (VWF) 异常的捐赠者很少被考虑进行肝移植.
低VWF活性,常见且往往无症状,对活体供体肝移植 (LDLT) 的影响表征不佳.

研究的目的:

报告一个成功的LDLT病例从一个边界低VWF活动的捐赠者.
在捐赠者和接受者中详细介绍术后和长期凝血概况.
评估低捐助者VWF活动对接受者的血液静止的影响.

主要方法:

来自具有轻微降低VWF活性的供体的LDLT病例报告.
在外科期间进行VWF/FVIII缩剂输注和监测.
在随访期间对捐赠者和接受者进行全面的凝血分析.

主要成果:

通过外科手术期间的VWF替代成功进行了LDLT;捐赠者没有出现并发症.
捐赠者的VWF参数在术后正常化,表明长期保持血静.
接收者在移植后保持稳定的VWF相关的凝血参数.

结论:

来自低VWF水平的捐赠者的LDLT在适当的术后管理下是安全的.
低捐助者VWF活性不一定会影响接受者的血液静止.
这些发现支持对LDLT的经过修订的供体资格评估.

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