作为料添加剂的N-乙半氨酸可以抵消禽类中甲毒素A的毒性
Muntaha Tanveer1,2, Muhammad Imran2, Muhammad Kashif Saleemi2
1Department of Zoology, Wildlife and Fisheries, Faculty of Sciences, University of Agriculture, Faisalabad, Pakistan.
概括
N-乙半氨酸 (NAC) 有效地保护肉免受Ochratoxin A (OTA) 毒性的影响. 补充NAC改善了生长,器官功能,并减少了由这种常见的家禽料污染物引起的组织损伤.
科学领域:
- 兽医毒理学 兽医毒理学
- 动物营养 动物营养
- 食品安全 食品安全
背景情况:
- 毒素A (OTA) 是一种污染家禽料的真菌毒素,对肉的健康和表现产生负面影响.
- 暴露于OTA会导致的显著生长障碍,免疫功能障碍和器官损伤.
- N-乙半氨酸 (NAC) 是一种抗氧化剂和谷氨前体,具有潜在的保护性质.
研究的目的:
- 评估N-乙半氨酸 (NAC) 在减轻Ochratoxin A (OTA) 诱导的肉中毒性的疗效.
- 评估NAC对与OTA暴露相关的临床病理学和组织病理学变化的影响.
- 为了比较NAC与商业毒素结合剂的保护作用.
主要方法:
- 125只肉被分为五组:对照组,OTA,NAC,OTA+NAC和OTA+毒素结合剂.
- 鸟类暴露于OTA (400μg/kg) 或补充NAC (100 mg/kg) 或毒素结合剂五周.
- 评估的参数包括临床症状,食摄入量,体重,血清生物化学和粗体/组织病理性病变.
主要成果:
- 暴露于OTA显著减少了料摄入量,体重增加和血清蛋白质.
- 肝脏和脏酶标记物 (ALT,AST,尿素,肌素) 的升高表明肝脏和脏受损严重.
- 补充NAC有效抵消了OTA的不良影响,恢复了性能和器官健康,与毒素结合剂相当.
结论:
- N-乙半氨酸 (NAC) 在 brojler中显示出显著的保护作用,防止Ochratoxin A (OTA) 毒性.
- NAC可以成为一种有价值,具有成本效益的料添加剂,用于预防家禽中与真菌毒素相关的健康问题.
- 进一步研究NAC在家禽料安全方面的作用是有必要的.
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