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谷氨 (GSH) 对2,4-二基酸 (2,4-D) 毒性的调节作用

Marzena Matejczyk¹, Edyta Juszczuk-Kubiak², Paulina Średnicka³

¹Faculty of Civil Engineering and Environmental Sciences, Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska 45E Str, Bialystok, 15-351, Poland. m.matejczyk@pb.edu.pl.

Scientific reports

|August 13, 2025

概括

这项研究表明,除草剂2,4-二基酸 (2,4-D) 是有毒且具有基因毒性,导致氧化应激. 谷氨 (GSH) 补充剂显著降低了这些有害影响,表明其在减轻农药诱导的细胞损伤和癌症风险方面的潜力.

科学领域:

环境毒理学环境毒理学
生物化学生物化学
分子生物学分子生物学

背景情况:

2,4-二基酸 (2,4-D) 是一种广泛使用的除草剂,具有显著的环境释放.
暴露于2,4-D与癌症风险增加有关,需要对其毒性机制进行调查.
天然抗氧化剂,如谷氨 (GSH),可以提供保护,防止农药引起的伤害.

研究的目的:

阐明2,4-D的毒性和基因毒性机制.
评估谷氨 (GSH) 补充剂对减轻2,4-D的不良影响的影响.
确认氧化应激作为2,4-D毒性的分子机制.

主要方法:

针对Enterobacter hormaechei和Candida albicans进行抗菌活性测定,以确定2,4-D毒性.
使用E. coli recA生物传感器菌株测量反应性氧物种 (ROS) 诱导的基因毒性评估.
酵母雌激素/雌激素查 (YES/YAS) 试验评估内分泌干扰潜力;对2,4-D/GSH混合物的评估.

主要成果:

2,4-D对E. hormaechei和C. albicans表现出毒性,对大肠杆菌表现出基因毒性,并增加了ROS合成.
在YES/YAS生物测试中没有检测到2,4-D的雌激素或雌激素活性.
谷氨 (GSH) 补充剂显著降低了2,4-D的毒性 (7-16%) 和基因毒性 (超过44%).

结论:

氧化应激是一种关键的分子机制,是2,4-D的毒性和基因毒性的基础.
谷氨 (GSH) 有效地减轻了2,4-D的不良细胞影响.
饮食中摄入富含谷氨的食物或补充剂可能对预防癌症和预防农药暴露至关重要.

关键词:

2,4-二基酸 (2,4-D) 的使用.癌症癌症癌症癌症雌激素/雄激素潜在的可能.基因毒性基因毒性微生物生物传感器有毒性有毒性

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