优化体内CYP3A4TDI测定条件的优化以及使用静态和动态模型进行临床DDI风险评估的衍生参数的使用

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

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Alessandra Pugliano1,2, Aynur Ekiciler3, Lena Preiss3

  • 1Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, F. Hoffmann-La Roche Ltd, CH-4070, Basel, Switzerland. alessandra.pugliano@roche.com.

The AAPS journal
|August 13, 2025
PubMed
概括

优化细胞内P450 3A4 (CYP3A4) 时间依赖性抑制试验的体外条件可以改善药物相互作用的预测. 基于生理学的药物动力学模型为CYP3A4 TDI评估提供了比机械静态模型更好的准确性.

关键词:
在 CYP3A4 中.药物相互作用 药物相互作用机械静态建模 机械静态建模基于生理学的药物动力学建模.时间依赖的抑制.

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