在男性精神分裂症中,面部帕雷多利亚背后的动态大脑通信是男性精神分裂症
Valentina Romagnano1, Julian Kubon1,2, Alexander N Sokolov1
1Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health (TüCMH), Medical School and University Hospital, Eberhard Karls University of Tübingen, Tübingen, Germany.
Schizophrenia (Heidelberg, Germany)
|August 13, 2025
概括
精神分裂症 (SZ) 患者对面部的反应显示出大脑活动的改变,影响了社会认知. 右LOC中的马振荡在SZ和典型发育个体之间有所不同,影响大脑通信.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 精神病学是一个精神病学.
背景情况:
- 面部处理对于社交互动至关重要,在精神分裂症 (SZ) 中显著改变.
- 患有SZ的人很难在pareidolia图像中感知面孔,与典型发育 (TD) 同龄人不同.
- 精神分裂症表现出扭曲的性别比率,这表明疾病表现中的性别差异.
研究的目的:
- 调查SZ和TD对照的男性之间面部感知中早期神经处理差异.
- 为了探索SZ.在面对pareidolia任务中大脑连接和马振荡的改变.
主要方法:
- 磁脑电图 (MEG) 在使用Arcimboldo类似的Face-n-Food图像进行面对对任务时的录制.
- 分析马振荡频率和地形.
- 在低 (40-45 赫兹) 和高 (65-70 赫兹) 马范围进行高级大脑连接分析.
主要成果:
- 在早期处理阶段,在SZ和TD个体之间观察到马振荡爆发 (频率和地形) 的差异.
- 面部反应期间40-45赫兹马活动的最大激活来自右侧尾复合体 (LOC).
- SZ个体表现出右LOC和社会大脑区域之间的沟通变化,对LOC的反有限.
结论:
- 早期的面部处理涉及与TD个体相比,SZ中具有明显的马振荡模式和连接性.
- 正确的LOC和社会大脑网络之间的通信变化有助于SZ的社会认知缺陷.
- 研究结果提供了对精神分裂症中社会认知障碍的神经支的见解.
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