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Updated: Sep 11, 2025

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与CCR4-NOT和PABPC1的多价值相互作用决定了tristetraprolin的mRNA抑制效率

Filip Pekovic1, Wi S Lai2, Joshua Corbo1

  • 1National Cancer Institute, National Institutes of Health, Frederick, MD, 21702, USA.

Nature communications
|August 13, 2025
PubMed
概括

特里斯特拉林蛋白通过与CCR4-NOT复合体和PABPC1.1相互作用来控制mRNA衰变. 酸化调节这些相互作用,影响mRNA的稳定性和降解.

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