基于虚拟现实的对比标准的认知行为治疗精神分裂症谱系障碍中的偏执症:一个随机对照试验
Ulrik N Jeppesen1,2, Ditte L Vernal3,4, Anne Sofie Due1
1VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Nature medicine
|August 13, 2025
概括
基于虚拟现实的偏执认知行为疗法 (VR-CBTp) 在减少精神分裂症谱系障碍中的偏执症方面没有显著优势. 需要进一步的研究来探索VR-CBTpp.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 数字健康数字健康
背景情况:
- 偏执是精神分裂症谱系障碍中常见和令人痛苦的症状.
- 基于虚拟现实的偏执症认知行为疗法 (VR-CBTp) 为暴露疗法提供受控环境.
- 这项研究将VR-CBTp与治疗偏执症的标准CBTp进行比较.
研究的目的:
- 调查VR-CBTp与标准CBTp相比在减少偏执症方面的有效性.
- 评估停止治疗后的治疗结果和六个月的随访.
主要方法:
- 一个评估者蒙面的,随机的平行组优越性试验.
- 254名患有精神分裂症谱系障碍的参与者被随机分配到VR-CBTp或CBTp的10次会议中.
- 主要结果是绿色偏执思想量表的"迫害思想"分量表.
主要成果:
- 在VR-CBTp和CBTp之间在终止治疗时的主要结果上没有发现统计学上显著的差异.
- 影响估计有利于VR-CBTp的2%,但这在统计上并不显著 (P=0.77).
- 没有报告死亡或暴力事件等不良事件.
结论:
- 没有发现VR-CBTp在减少精神分裂症谱系障碍中的偏执症方面优于标准CBTp.
- 目前的发现表明,VR-CBTp对于这种症状可能不会比传统的CBTp提供额外的好处.
- 需要进一步研究VR-CBTp的治疗潜力.
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