RegNetwork 2025:人类和小鼠基因调节网络的综合数据库
Bowen Li1, Chuanyuan Wang1, Yijuan Wang1,2
1Department of Biomedical Engineering, School of Control Science and Engineering, Shandong University, Jinan, Shandong 250061, China.
Nucleic acids research
|August 13, 2025
概括
RegNetwork 2025显著扩展基因调控网络数据,包括长非编码RNA和循环RNA. 这种全面的数据库增强了对基因相互作用的理解,为研究人员提高了可靠性评分.
科学领域:
- 生物信息学是一种生物信息学.
- 基因组学就是基因组学.
- 系统生物学 系统生物学
背景情况:
- 基因调节网络 (GRNs) 对于理解细胞过程至关重要.
- 现有的GRN数据分散在多个资源中,阻碍了研究.
- 一个统一可靠的GRN数据库对于生物发现至关重要.
研究的目的:
- 介绍RegNetwork数据库的更新和扩展版本.
- 整合新的调控元素,如长非编码RNA (lncRNA) 和圆形RNA (circRNA).
- 为研究界提高GRN数据的可靠性和可访问性.
主要方法:
- 从各种数据源中对监管关系的全面策划.
- 包括转录因子 (TFs),microRNAs (miRNAs),lncRNAs和circRNAs. 这些都包括在内.
- 开发监管互动的信任评分系统.
主要成果:
- RegNetwork 2025包含125,319个节点和11,107,799个监管相互作用.
- 与之前的版本相比,监管互动的增加>95%.
- 引入lncRNA和circRNA数据,丰富了数据库.
结论:
- RegNetwork 2025为GRN研究提供了显著扩展和更可靠的资源.
- 该数据库有助于更深入地了解复杂的基因相互作用.
- 自由获取的数据促进了人类和小鼠基因组学的进步.
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