在胃肠道手术后,将7天的D-二聚物暴露与深静脉血栓症风险预测相结合,预测了胃肠道手术后的风险
Shuwei Weng1,2,3, Chen Ding3, Die Hu1,2
1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Scientific reports
|August 13, 2025
概括
一个新的指标,七天D-二次体暴露 (7dDDE),有效预测胃肠道手术后的深静脉血栓 (DVT). 这种累积测量可以通过考虑凝血负担的时间变化来改善标准的D-二次体测试.
科学领域:
- 生物医学工程 生物医学工程
- 临床医学 临床医学
- 血栓形成研究研究
背景情况:
- 深静脉血栓症 (DVT) 是胃肠道手术后的一个重大风险.
- 由于炎症,标准的D-二聚体测试在术后具有有限的特异性.
- 准确地对DVT进行术后风险分层仍然是一个临床挑战.
研究的目的:
- 引入和验证一种新的累积生物标志物,即为期7天的D-二次体暴露 (7dDDE),用于评估外科手术期间的凝血负担.
- 为了评估7dDDE在经过胃肠道手术后术后DVT的预测性.
- 探索纵向D-二次元模式在DVT风险评估中的有用性.
主要方法:
- 对525名经过胃肠道手术的患者进行了回顾性分析.
- 倾向性得分匹配和多变量逻辑回归,包括7dDDE和临床变量.
- 模型性能评估使用ROC曲线,决策曲线分析,校准图,SHAP值和名ogram构造.
- 线性混合效应建模以分析随时间推移的D-二次体轨迹.
主要成果:
- 七天D-二聚合物暴露 (7dDDE) 独立地与手术后的DVT相关,并成为最有影响力的预测因素.
- 开发的预测模型显示出良好的区别和临床效用.
- 纵向分析显示,DVT和非DVT组之间的D-二次体动态不同,即使经过对混因子进行调整.
结论:
- 在接受胃肠道手术的患者中,为期7天的D-二元体暴露 (7dDDE) 作为分层血栓风险的强有力的生物标志物.
- 整合时间生物标志物模式,如7dDDE,增强了外科手术期间DVT的预测.
- 这种新型指标在术后DVT风险评估中比传统的D-二次元测量提供了更高的准确性.
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