心理脆弱指数和中风之间的关联:来自CHARLS的队列研究
Mixue Guo1, Zufa Zhang2, Huqiang Dong3
1School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, Ningxia, China.
Scientific reports
|August 13, 2025
概括
通过心理虚弱指数 (PFI) 衡量心理脆弱性,显著增加了中风风险. 较高的PFI分数与患中风的可能性更高有关,这凸显了它在中风预防策略中的重要性.
科学领域:
- 老年学与公共卫生
- 心血管流行病学心血管流行病学
- 心理健康研究 心理健康研究
背景情况:
- 脑卒中是全球死亡和残疾的主要原因之一,特别影响着老年人口.
- 心理脆弱性是公认的心理健康状况,但它与中风的关联缺乏广泛的研究.
- 心理脆弱性指数 (PFI) 为评估心理脆弱性提供了可量化的衡量标准.
研究的目的:
- 调查PFI量化的心理脆弱性与中风风险之间的关系.
- 探索剂量-反应关系和这种关联中的潜在改变因素.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的15284名参与者 (≥45岁) 的基线数据.
- 采用考克斯逻辑回归和受限立方线 (RCS) 分析来评估PFI-中风风险关联.
- 进行了子组分析和相互作用测试,以检查不同人口群体之间的变化.
主要成果:
- 在PFI和意外中风风险之间发现了显著的正线性关联.
- 每增加1个IQR的PFI与中风风险增加87%相关 (HR=1.87).
- 与最低四分位数 (HR=3.12) 相比,PFI四分位数最高的参与者面临的中风风险增加了三倍以上.
结论:
- 心理脆弱性是增加中风风险的重要,独立的预测因素.
- 评估心理脆弱性应纳入全面的中风预防策略.
- 应特别注意老年人和有社会支持不足的人.
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