使用乙烯乙烯醇 (EVOH) 聚合物进行前列腺动脉栓塞治疗良性前列腺增生:十二个月分析
Jacques Sédat1, Eric Fontas2, Paolo Arnoffi3
1Service d'Interventionnel Neurologique et Général, CHU de Nice, Hôpital Pasteur 2, 30 Voie Romaine, Nice, France. jsedat@yahoo.fr.
Cardiovascular and interventional radiology
|August 13, 2025
概括
使用乙烯乙烯酒合聚合物进行前列腺动脉栓塞是良性前列腺增生的一个安全程序. 虽然它改善了尿路症状,但它并没有显著减少前列腺体积或12个月后空虚的残留体积.
科学领域:
- 干预性泌尿器科 干预性泌尿器科
- 血管干预放射学 血管干预放射学
背景情况:
- 良性前列腺增生症 (BPH) 导致下泌尿道症状 (LUTS).
- 前列腺动脉栓塞 (PAE) 是BPH的新兴治疗方法.
- 乙烯乙醇合聚合物 (EVOH) 是PAE的潜在栓塞剂.
研究的目的:
- 评估PAE与EVOH的可行性,安全性和12个月的结果,用于BPH相关的LUTS.
- 评估PAE对国际前列腺症状评分 (IPSS),生活质量 (IPSS-QoL),前列腺体积和空洞后残留体积 (PVR) 的影响.
主要方法:
- 一个单一中心前性研究包括12名连续患有中度至重度LUTS和前列腺扩大 (体积>40毫升) 的患者.
- 没有包括患有前列腺癌或晚期动脉样硬化症的患者.
- 在12个月后使用IPSS,IPSS-QoL,前列腺体积和PVR体积来评估结果. 用混合效应模型分析数据.
主要成果:
- 双边PAE与EVOH在技术上在所有患者中都是成功的,没有重大不良事件.
- 在IPSS (17.9至9.3,P=0.03) 和IPSS-QoL (4.8至2.1,P=0.01) 的12个月后,观察到有统计学意义的改善.
- 在PVR体积 (57.3至41.5毫升,P=0.9) 或前列腺体积 (89.2至82.7毫升,P=0.6) 中没有显著变化.
结论:
- 带有EVOH的PAE是BPH的安全治疗选择.
- 该程序在12个月后改善LUTS和生活质量方面表现出有效性.
- 需要进行更多随机随访试验,以证实这些发现,并评估对前列腺和PVR体积的长期影响.
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