高血糖和不良结果之间的关联在急性缺血性中风中成功进行血栓切除的患者中:单中心研究
Ao Qian1, Longyi Zheng2, Shuang Tang1
1Department of Cerebrovascular Disease, Suining Central Hospital, No.27 of Dongping North Road, Hedong New District, Suining, Sichuan, 629000, China.
BMC neurology
|August 14, 2025
概括
过高血糖和血糖水平升高与机械血栓切除术后急性缺血性中风患者的病情恶化有关. 系统性炎症在这种关联中起着部分作用,突出显示了血糖控制的重要性.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 关键护理医学 关键护理医学
背景情况:
- 高血糖是急性缺血性中风 (AIS) 的常见并发症.
- 机械血栓切除术 (MT) 是AIS的关键治疗方法,但结果可能会变化.
- 葡萄糖动态对MT后结果的影响需要进一步研究.
研究的目的:
- 调查高血糖,血糖水平动态和接受MT的AIS患者不良结果之间的关联.
- 探索系统性炎症作为这些关联中介者的作用.
主要方法:
- 对395名接受MT治疗的AIS患者进行了回顾性研究.
- 在入院时,MT后和第二天早上禁食测量血糖水平.
- 高血糖症定义为≥8 mmol/L;根据修改的兰金度量表,不良结果在90天内超过2.
- 使用多变量逻辑回归和调解分析.
主要成果:
- 住院,术后和禁食高血糖症独立地与不良结果相关.
- 禁食血糖增加 (BGI) 也是一个显著的危险因素.
- 系统性炎症部分介导过高血糖和不良结果之间的关系 (10.4-21.8%介导).
结论:
- 高血糖和禁食BGI与MT治疗的AIS患者不良后果的风险增加有关.
- 系统性炎症是这些关联的部分调解者.
- 这些发现强调了在接受MT的AIS患者中葡萄糖管理的重要性.
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