习惯性寒冷暴露对北极成年人棕色脂肪组织活动的影响:系统性审查
Mette Motzfeldt Jensen1,2, Martin Grønbech Jørgensen1,3, Charlotte Elberling Almasi1,4
1Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
International journal of circumpolar health
|August 14, 2025
概括
北极地区的成年人表现出高棕色脂肪组织 (BAT) 活动,这对寒冷适应至关重要. 这一发现支持了BAT.
科学领域:
- 人类生理学 人类生理学
- 热生成是一种热生成.
- 环境适应环境适应
背景情况:
- 棕色脂肪组织 (BAT) 对于不发的热生成至关重要.
- 在成年人中使用BAT的存在为代谢性疾病的治疗提供了潜力.
- 北极地区的人口经历了习惯性的寒冷暴露,需要适应机制.
研究的目的:
- 系统地审查北极成年人棕色脂肪组织活动的证据.
- 描述BAT在这些人群适应习惯性寒冷暴露中的作用.
主要方法:
- 在2024年11月之前进行系统的文献搜索 (PubMed,Embase,Scopus).
- 包括使用NIH质量评估工具评估的研究.
- 八项研究符合纳入标准;由于异质性,没有进行元分析.
主要成果:
- 有证据表明,在北极成年人中,BAT活动很高.
- 这些指标包括寒冷暴露后肌肤上关节温度的升高.
- 甲状腺激素动态和遗传标记也支持这些发现.
结论:
- 棕色脂肪组织在北极居民的寒冷适应中起着重要作用.
- 由于当前研究的方法限制,需要进一步的研究.
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