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COVID-19器官损伤病理和D-Dimer表达模式:一个回顾性分析
Raluca Dumache1,2, Camelia Oana Muresan1,2, Sorina Maria Denisa Laitin3
1Department of Forensic Medicine, Bioethics, Medical Ethics and Medical Law, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Diagnostics (Basel, Switzerland)
|August 14, 2025
概括
在COVID-19患者中,D-二聚合物水平的升高与多器官损伤的增加有关,特别是在肺和心脏. 这突显了高凝结能力.
科学领域:
- 病理学 病理学 病理学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 冠状病毒疾病2019 (COVID-19) 可能导致广泛的器官损伤.
- 过高凝血,以升高的D-二次体表示,是已知的COVID-19并发症.
- 在COVID-19中,D-二聚合物水平与特定器官病理之间的关系需要进一步阐明.
研究的目的:
- 为了评估COVID-19患者的病理变化.
- 分析器官特异性损伤与D-二次体水平相关.
- 为了调查D-二次体在COVID-19结果中的预后意义.
主要方法:
- 对69名COVID-19尸检或已死亡患者的回顾性审查.
- 病理发现的目录:肺微血栓,支气管肺炎,心肌纤维化,肝硬化,管性瘤.
- 基于D-二次元类别 (<500,500-2000,≥2000 ng/mL) 的子组分析和与临床/实验室数据的相关性.
主要成果:
- 标志性器官病理在最高的D-二次体组 (≥2000 ng/mL) 发生频率明显高.
- 肺部,心肌和脏病变的患病率增加,D-二次体水平更高.
- 严重的肺和心脏病理与高的炎症标志物相关,并增加了ICU入院和死亡的风险.
结论:
- 与COVID-19相关的器官损伤在患有显著升高D-二次数的患者中被放大.
- 高凝血和全身炎症在多器官并发症中起着至关重要的作用.
- D-二次元分层可以指导高风险COVID-19患者的量身定制管理.
关键词:
在 COVID-19 疫情中,D-二聚子 D-二聚子这就是SARS-CoV-2病毒.生物标志物 生物标志物凝血病是一种凝血病.诊断 诊断 诊断 诊断 诊断 诊断免疫和炎症调解剂 免疫和炎症调解剂器官受伤器官受伤器官受伤器官受伤器官受伤器官病理学的病理学更多相关视频
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