在患有急性胰腺炎的患者中,近腹小肠的微生物组
Vladimir V Kiselev1, Stanislav I Koshechkin2, Alexey V Kurenkov1
1Sklifosovsky Research Institute for Emergency Medicine, 3 Bolshaya Sukharevskaya Square, 129090 Moscow, Russia.
Diagnostics (Basel, Switzerland)
|August 14, 2025
概括
小肠道的微生物群.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 关于上部胃肠道疾病中小肠道微生物群的数据有限.
- 了解肠道微生物组在急性胰腺炎中的作用至关重要.
研究的目的:
- 在急性胰腺炎中描述小肠微生物组.
- 为了将微生物组组成与疾病严重程度和临床因素相关联.
主要方法:
- 从骨样本中测序16S rRNA基因的元基因组测序.
- 对30名患有不同严重程度急性胰腺炎的患者的分析.
主要成果:
- 小肠微生物组主要由链球菌,Veillonella和Granulicatella组成.
- 严重的胰腺炎显示Neisseria 粘膜,Parvimonas micra 和Megasphaera micronuciformis的减少.
- 在严重的病例中观察到链球菌,Actinomyces和Enterobacteriaceae的丰富性增加.
结论:
- 小肠微生物群在急性胰腺炎中具有预后价值.
- 微生物组的变化与疾病的严重程度和治疗延迟有关.
相关概念视频
Acute Pancreatitis I: Introduction
486
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
486
Acute Pancreatitis II: Clinical Manifestations and Management
176
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
176
Chronic Pancreatitis I: Introduction
157
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
157
Anatomy of the Intestines
74.0K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
74.0K
Histology of the Small Intestine
1.6K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
1.6K
Chronic Pancreatitis II: Collaborative Care
128
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
128


