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Updated: Sep 11, 2025

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鸟类线粒体衍生MOTS-c的表征及其作为代谢调节剂的潜在作用

Xin Shu¹, Jiying Liu^1,2, Bingjie Xu¹

¹Jiangsu Key Laboratory of Sericultural and Animal Biotechnology, School of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, China.

Animals : an open access journal from MDPI

|August 14, 2025

概括

这项研究确定和描述了鸟类MOTS-c,一种线粒体,揭示了其进化保护及其在家禽中的潜在代谢作用. 这些发现突出了保存的残留物和通路激活,为未来的鸟类研究铺平了道路.

科学领域:

线粒体遗传学和的演变.
比较基因组学和生物信息学
鸟类生理学和新陈代谢

背景情况:

12S rRNA type c (MOTS-c) 的线粒体开放读取框架对于哺乳动物的能量代谢,基因表达和免疫是至关重要的.
关于MOTS-c的研究仅限于哺乳动物物种,在鸟类种群中之前没有报告.

研究的目的:

在主要家禽物种中识别和描述MOTS-c编码序列.
研究鸟类MOTS-c.的进化保护和功能作用.

主要方法:

对鸟类和哺乳动物MOTS-c序列的生物信息学分析.
对mRNA和蛋白质序列的遗传学分析.
肉的组织表达特征分析MOTS-c.
初级肝细胞的功能分析和西方斑点验证.

主要成果:

在鸟类和哺乳动物MOTS-c编码区域中观察到高度的序列相似性,在鸟类序列中显著的单核酸删除.
遗传学分析表明,鸟类和哺乳动物的MOTS-c.具有不同的进化路径.
肉MOTS-c分布广泛,最高的表达在心脏中,禁食后会减少.
在肝细胞中MOTS-c治疗激活了核糖体,氧化酸化,PI3K-AKT和JAK-STAT通路,证实了AKT通路的激活.

结论:

这项研究提供了鸟类MOTS-c的第一个全面表征,揭示了它与哺乳动物同类的进化分歧.
鸟类MOTS-c表现出潜在的代谢调节功能,特别是在心脏中,并影响关键的细胞通路.
这些发现为探索鸟类物种中线粒体编码的功能奠定了基础.

关键词:

在 AKT 信号通道上.这就是MOTS-cc.在RNA-seqqq.这是一种线粒体衍生.禽类禽类禽类禽类

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